The 5th IASTED African Conference on
Modelling and Simulation
AfricaMS 2014

September 1 – 3, 2014
Gaborone, Botswana


From cells to tissue: modelling the electrophysiology of the human heart

Prof. Kevin Burrage
University of Oxford, United Kingdom


In this seminar I first give a brief overview of cell models for modelling the electrophysiology of the heart starting with the Hodgkin Huxley equations. I then discuss how these ionic models can be incorporated into tissue models and then whole organ models of the heart. Finally I describe some clinical data associated with hypertrophic cardiomyopathy (in which the fibres of the heart undergo disarray) and show how continuum models based on non-local operators, so called fractional diffusion, can be used to gain deep insights into the nature of this disease.

Biography of the Keynote Speaker

Keynote Speaker Portrait

Prof. Burrage joined Oxford University in early 2008 and is now Professor of Computational Systems Biology at the Department of Computer Science, University of Oxford and the Oxford Centre for Integrative Systems Biology. He is a member of the Computational Cardiac Modelling and Simulation group within Computer Science.
He shares his time, half and half, between Oxford and the Mathematics Department at the Queensland University of Technology (QUT, Brisbane, Australia, where he is Professor of Computational Mathematics. He is also a theme leader in the new Institute for Future Environments at QUT
Prof. Burrage was a supernumerary fellow of New College at Oxford University between 2008-2012. Before coming to Oxford he was a Federation Fellow of the Australian Research Council (2003-2008) at the University of Queensland.